Forkhead box P3 and indoleamine 2,3-dioxygenase co-expression in Pakistani triple negative breast cancer patients

Table 4 Patients and tumor characteristics of forkhead box P3 negative vs positive

Variables	Characteristics	FOXP3 negative 75 (75.0%)	FOXP3 positive 25 (25.0%)	P value
Age (yr)	mean ± SD	48.60 ± 11.02	47.32 ± 14.20	0.64
IDO score	Low	22 (91.7%)	2 (8.3%)	0.01a
	Medium	23 (85.2%)	4 (14.8%)
	High	30 (61.2%)	19 (38.8%)
Grade	II	28 (80.0%)	7 (20.0%)	0.21
	III	38 (67.9%)	18 (32.1%)
Metastasis	Negative	27 (71.1%)	11 (28.9%)	0.45
	Positive	39 (79.6%)	10 (20.4%)
Tumor size	T1	4 (57.1%)	3 (42.9%)	0.15
	T2/T3	46 (80.7%)	11 (19.3%)
Lymph nodes involvement	Negative	26 (70.3%)	11 (29.7%)	0.29
	Positive	40 (80.0%)	10 (20.0%)
Estrogen receptor	Negative	48 (69.6%)	21 (30.4%)	0.06
	Positive	27 (87.1%)	4 (12.9%)
Progesterone receptor	Negative	52 (70.3%)	22 (29.7%)	0.06
	Positive	23 (88.5%)	3 (11.5%)
HER2–neu receptor	Negative	53 (71.6%)	21 (28.4%)	0.19
	Positive	22 (84.6%)	4 (15.4%)
Triple negative breast cancer	No	44 (86.3%)	7 (13.7%)	0.01a
	Yes	31 (63.3%)	18 (36.7%)

^aP < 0.05. IDO: Indoleamine 2,3-dioxygenase; HER2: Human epidermal growth factor receptor; FOXP3: Forkhead box P3; SD: Standard deviation.