Evaluation of a locked nucleic acid form of antisense oligo targeting HIF-1α in advanced hepatocellular carcinoma

doi:10.5306/wjco.v10.i3.149

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Mar 24, 2019; 10(3): 149-160
Published online Mar 24, 2019. doi: 10.5306/wjco.v10.i3.149

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Figure 3 Biomarker analysis plan to dissect mechanism of action of hypoxia inducible factor-1αlpha inhibitors. HIF-1α: Hypoxia inducible factor-1αlpha; HIF2: Hypoxia inducible factor 2; HIF-1α mRNA: Hypoxia inducible factor 1-alpha messenger ribonucleic acid; EPO: Erythropoietin; VEGF: Vascular epidermal growth factor; IHC: Immunohistochemistry; vWF: Von willebrand factor; CD34: Cluster of differentiation 34; PR: Partial response; DCE-MRI: Dynamic contrast-enhanced magnetic resonance imaging; RECIST: Response evaluation criteria in solid tumors.

Citation: Wu J, Contratto M, Shanbhogue KP, Manji GA, O’Neil BH, Noonan A, Tudor R, Lee R. Evaluation of a locked nucleic acid form of antisense oligo targeting HIF-1α in advanced hepatocellular carcinoma. World J Clin Oncol 2019; 10(3): 149-160
URL: https://www.wjgnet.com/2218-4333/full/v10/i3/149.htm
DOI: https://dx.doi.org/10.5306/wjco.v10.i3.149