Evaluation of a locked nucleic acid form of antisense oligo targeting HIF-1α in advanced hepatocellular carcinoma

Figure 1 Concentrations of RO7070719 in normal mouse liver, Hep3B orthotopic tumor and specimens harvested at Day 39. A: Concentrations of RO7070719 in normal liver; B, C: Hep3B tumor xenograft and the levels of HIF-1α mRNA in (C) normal liver; D: Hep3B tumor xenograft. Normal mouse liver (A) and Hep3B orthotopic tumor (B) specimens harvested at Day 39 (n = 10/group, except at 30 mg/kg n = 3/group harvested at Day 23) were quantified using hybridization-ELISA for RO7070719 concentrations. The levels of HIF-1a mRNA were quantified by qPCR in normal liver (C), and Hep3B orthotopic tumor xenografts (D).