Evaluation of a locked nucleic acid form of antisense oligo targeting HIF-1α in advanced hepatocellular carcinoma

doi:10.5306/wjco.v10.i3.149

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Mar 24, 2019 (publication date) through Sep 9, 2024

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Mar 24, 2019; 10(3): 149-160
Published online Mar 24, 2019. doi: 10.5306/wjco.v10.i3.149

Table 2 Fold of changes in hypoxia inducible factor-1αlpha mRNA by qPCR

Number	Patient ID	Specimen 1 at tip site(fold changed)	Specimen 2 at root site(fold changed)
1¹	2886230004 (super-responder) ¹	0.9¹	0.19¹

Specimen 1 is the tip of the biopsy, and specimen 2 is the other end of biopsy. A difference in the number of cycles was assumed to be a 2-fold difference.

¹The results of the patient who had a robust clinical response in partial response.

Citation: Wu J, Contratto M, Shanbhogue KP, Manji GA, O’Neil BH, Noonan A, Tudor R, Lee R. Evaluation of a locked nucleic acid form of antisense oligo targeting HIF-1α in advanced hepatocellular carcinoma. World J Clin Oncol 2019; 10(3): 149-160
URL: https://www.wjgnet.com/2218-4333/full/v10/i3/149.htm
DOI: https://dx.doi.org/10.5306/wjco.v10.i3.149