Existing anti-angiogenic therapeutic strategies for patients with metastatic colorectal cancer progressing following first-line bevacizumab-based therapy

doi:10.5306/wjco.v10.i2.52

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Feb 24, 2019 (publication date) through Nov 28, 2024

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Feb 24, 2019; 10(2): 52-61
Published online Feb 24, 2019. doi: 10.5306/wjco.v10.i2.52

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Figure 1 Approved anti-vascular endothelial growth factor monoclonal antibodies in the treatment of metastatic colorectal cancer and their mechanisms of action. VEGF: Vascular endothelial growth factor; PIGF: Placental growth factor; FAK: Focal adhesion kinase; PI3K: Phosphoinositide 3-kinase; PLC-γ: Phospholipase C gamma; PKC: Protein kinase C; MAPK: Mitogen-activated protein kinases; Erk: Extracellular signal-regulated kinase.

Citation: Kanat O, Ertas H. Existing anti-angiogenic therapeutic strategies for patients with metastatic colorectal cancer progressing following first-line bevacizumab-based therapy. World J Clin Oncol 2019; 10(2): 52-61
URL: https://www.wjgnet.com/2218-4333/full/v10/i2/52.htm
DOI: https://dx.doi.org/10.5306/wjco.v10.i2.52