Oligometastases in prostate cancer: Ablative treatment

Table 2 Summary of selected publications reporting stereotactic body radiation therapy for lymph nodes oligometastatic prostate cancer

Ref.	Study type	No. Patients / lesions	No. of metastases	Imaging method	Site of metastases	SBRT schedules	LC	PFS
Lymph node
Casamassima et al[33]	R	25/25	NR	Cholina PET/CT	LN	N = 18: 30 Gy/3 fr	90% (3 yr)	Median 24 mo
Detti et al[36]	R	30/39	NR	Cholina PET/CT	LN	24-36 Gy/1-5 fr	100% (1 yr)	NR
Ponti et al[60]	R	16/18	≤ 2	Cholina PET/CT	LN	12-35 Gy/1-5 fr	94% (2 yr)	NR
Ost et al[29]	R	72/89	≤ 3	18F-FDG, Cholina PET/CT,MRI	LN	At least 5 Gy/fr with BED at least 80 Gy	95.8% (3 yr)	Median 21 mo 34% (3 yr) 13% (5 yr)
Ingrosso et al[61]	R	40/47	NR	Cholina PET/CT	LN	35-40 Gy/5 fr (+ frequent)	98% (mean FU 30 mo)	NR
Jereczek-Fossa et al[62]	R	94/124	≤ 5	Cholina PET/CT/CT/MRI	LN	24-30 Gy/3 fr (+ frequent)	84% (2 yr)	30% (2 yr)

BED: Biologically effective dose; CT: Computed tomography; 18F-FDG: [18F]-fluorodeoxyglucose; LC: Local control; LN: Lymph node; MRI: Magnetic resonance imaging; NR: Not reported; PET/CT: Positron emission tomography with coregistered computed tomography; PFS: Progression free survival; R: Retrospective; SBRT: Stereotactic body radiation therapy.