Role of Mediterranean diet in preventing platinum based gastrointestinal toxicity in gynecolocological malignancies: A single Institution experience

Table 5 Gastrointestinal toxicities’ score after last chemotherapy cycle in the whole study population and in the two study’s groups according to the Mediterranean diet serving score

	MDSS ≥ 13	MDSS < 13	Total	P value
Dry mouth (G)	1.5 ± 1.8	0.8 ± 1.8	1.2 ± 1.7	0.53
Dysphagia (G)	0 ± 0	0.2 ± 0.4	0.1 ± 0.3	0.24
Oral sores (G)	0 ± 0	0 ± 0	0 ± 0	1
Oral sores (A)	0 ± 0	0 ± 0	0 ± 0	1
Mouth’s cracks (G)	0 ± 0	0.2 ± 0.4	0.1 ± 0.3	0.24
Dysgeusia (G)	1.3 ± 1.5	2.6 ± 1.9	1.9 ± 1.8	0.23
Loss of appetite (G)	1.3 ± 1.5	2.4 ± 1.7	1.8 ± 1.6	0.28
Loss of appetite (I.A)	1.3 ± 1.5	2 ± 1.4	1.6 ± 1.4	0.44
Nausea (F)	0.7 ± 1.6	3.6 ± 0.9	2 ± 2	< 0.01
Nausea (G)	0.7 ± 1.6	3.4 ± 0.9	1.9 ± 1.9	< 0.01
Vomiting (F)	0.3 ± 0.8	0.8 ± 1.3	0.5 ± 1	0.45
Vomiting (G)	0.2 ± 0.4	1 ± 1.7	0.5 ± 1.2	0.28
Stomach ache (F)	0 ± 0	1 ± 1	0.5 ± 0.8	0.03
Stomach ache (G)	0 ± 0	1.2 ± 1.3	0.5 ± 1	0.04
Gas (yes/no)	0.3 ± 0.5	0.4 ± 0.5	0.4 ± 0.5	0.74
Bloating (F)	0 ± 0	1.4 ± 1.3	0.6 ± 1.1	0.02
Bloating (G)	0 ± 0	1 ± 1	0.5 ± 0.8	0.03
Constipation (G)	0.8 ± 0.4	2.4 ± 1.8	1.5 ± 1.4	0.06
Diarrhea (F)	0.5 ± 0.8	1.2 ± 1.1	0.8 ± 1	0.25
Abdomen ache (F)	0.2 ± 0.4	1.4 ± 0.9	0.7 ± 0.9	0.01
Abdomen ache (G)	0.2 ± 0.4	1.2 ± 0.8	0.6 ± 0.8	0.02
Abdomen ache (I.A)	0.2 ± 0.4	1.2 ± 0.8	0.6 ± 0.8	0.02
GI toxicity (TOT)	9.5 ± 10.9	29.4 ± 10.4	18.5 ± 14.5	0.01

I.A: Interference with daily activities; MDSS: Mediterranean diet serving score; G: Gravity; F: Frequency; TOT: Time of treatment; GI: Gastrointestinal.