Radiation-induced malignant rhabdoid tumour of the hypothalamus in an adult: A case report

doi:10.5306/wjco.v10.i11.375

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World Journal of Clinical Oncology

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Report

World J Clin Oncol. Nov 24, 2019; 10(11): 375-381
Published online Nov 24, 2019. doi: 10.5306/wjco.v10.i11.375

Table 2 Summary of immunohistological findings of radiation-induced malignant rhabdoid tumour

Case	*Padua et al[1]*	*Kuge et al[2]*	*Gorayski et al[3]*	*Oliveira et al[4]*	Our case
Vimentin	+	+	+	+	+
EMA	+	+	+	+	-
SMA	NA	+	+	NA	-
INI 1	-	-	-	-	NA
GFAP	-	-	-	+	+
NFP	NA	-	+	+	NA
S100	NA	+	-	NA	NA
CK:	-	NA	-	NA
CKAE1/AE3					+
CK7
CK20
Chromosome 22q deletion	NA	NA	NA	+	NA
Desmin	-	NA	-	NA	-
LCA	-	NA	-	NA	-
Ki67	NA	7.8%	NA	NA	>20%
Others (stain positive)	Neuron-specific enolase	NA	CD99	NA	CD138, CD68,
Others (stain negative)	CD99, Tdt, myeloperoxidase	NA	HMB45, CD34, CD31, CD10, PLAP, MelanA, MYOD1, myogenin, chromogranin, p63	NA	Synaptophysin, HMB45, CD117, CD79, CD30, Tdt, PLAP

CD: Cluster of differentiation; CK: Cytokeratin; EMA: Epithelial membrane antigen; GFAP: Glial fibrillary acidic protein; HMB: Human melanoma black; INI 1: Integrase interactor 1; LCA: Leukocyte common antigen; MYOD: Myoblast determination protein; NA: Not applicable; NFP: Neurofilament protein; PLAP: Placental alkaline phosphatase; SMA: Smooth muscle actin; Tdt: Terminal deoxynucleotidyl transferase.

Citation: Ng PM, Low PH, Liew DNS, Wong ASH. Radiation-induced malignant rhabdoid tumour of the hypothalamus in an adult: A case report. World J Clin Oncol 2019; 10(11): 375-381
URL: https://www.wjgnet.com/2218-4333/full/v10/i11/375.htm
DOI: https://dx.doi.org/10.5306/wjco.v10.i11.375