Long-term outcomes of interventions for radiation-induced xerostomia: A review

Table 6 Other

Author	Type of study	Sample size	Intervention	Xerostomia symptoms	Salivary function	Quality of life	Toxicity
Wong et al[54], 2015	Phase III randomized controlled trial	148	ALTENS vs oral PC (5 mg TID for 12 wk)	NA	Basal WSP and stimulated WSP: no sig difference	XeQOLs: no difference at 15 mo. 83% ALTENS positive responders vs 62.8% PC, SS at 15 mo.	2 G3 events in PC (dry mouth, blurry vision) vs 1 G3 event in ALTENS (headache). 61.6% of PC had Grade 3 or less non-hematologic AEs vs 20.9% of ALTENS
Teguh et al[52], 2009	randomized controlled trial	19	Hyperbaric O2 (30 sessions at 2.5 ATA with O2 breathing for 90 min daily, 5 d a week) vs control	Visual analogue scale dry mo better on O2 (SS)	NA	EORTC QLQ-C30 and H and N35; Sticky saliva better on O2 (SS) and less dry mouth on O2 (SS)	NA
Blom et al[53], 1996	randomized placebo-controlled trial	38	acupuncture vs placebo (superficial acupuncture)	NA	salivary flow rate: no dif. between groups; both groups showed increased flow rates after treatment	No specific endpoints	Tiredness, small haematomas at acupuncture sites

ALTENS: Acupuncture like transcutaneous electrical nerve stimulation; NA: Not available; G: Grade; PC: Pilocarpine; AE: Adverse event; WSP: Whole salivary production; XeQOLs: Xerostomia quality of life scale.