Coeliac disease in the modern era: Severity of small bowel mucosal injury at diagnosis with analysis of clinical correlates and rate of improvement on a gluten free diet

Table 4 Symptoms, serology and histology results for 99 patients divided by severity of duodenal histology at initial biopsy

Biopsy score1	n (%)	Positive serology2	Symptoms at diagnosis (%)
0	0 (0)	-	-
1	7 (7)	Positive = 7 (100)	0 (0)
		Negative = 0 (0)
		Unknown = 0 (0)
2	2 (2)	Positive = 2 (100)	2 (100)
		Negative = 0 (0)
		Unknown = 0 (0)
3a	29 (29)	Positive = 25 (86)	14 (48)
		Negative = 4 (14)
		Unknown = 0 (0)
3b	12 (12)	Positive = 10 (83)	7 (58)
		Negative = 1 (8)
		Unknown = 1 (8)
3c	49 (49)	Positive = 44 (90)	25 (51)
		Negative = 2 (4)
		Unknown = 3 (6)

¹Marsh-Oberhuber score at diagnosis;

²tissue Transglutaminase antibodies or endomysial antibodies.