Combination therapy for inflammatory bowel disease

doi:10.4292/wjgpt.v8.i2.103

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World Journal of Gastrointestinal Pharmacology and Therapeutics

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2150-5349

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pharmacol Ther. May 6, 2017; 8(2): 103-113
Published online May 6, 2017. doi: 10.4292/wjgpt.v8.i2.103

Table 1 Author’s summary of the evidence for combination therapy

	Crohn’s disease		Ulcerative colitis
	Clinical benefit	Pharmacokinetic/immunogenic benefit	Clinical benefit	Pharmacokinetic/immunogenic benefit
IFX + AZA/6MP (treatment naïve)	+	+	+	+
IFX + AZA/6MP (step-up from immunomodulator monotherapy)	-	NA	NA	NA
IFX + MTX	+/-	+	NA	NA
ADA + IMM	+/-	+/-	NA	NA
VDZ + IMM	NA	+	NA	NA
Ustekinumab +	NA	NA	NA	NA
IMM	NA	NA	NA	NA

IFX: Infliximab; AZA: Azathioprine; 6-MP: 6-mercaptopurine; MTX: Methotrexate; ADA: Adalimumab; VDZ: Vedolizumab; IMM: immunomodulatory; +: beneficial; +/-: Possible benefit; NA: No adequate data available.

Citation: Sultan KS, Berkowitz JC, Khan S. Combination therapy for inflammatory bowel disease. World J Gastrointest Pharmacol Ther 2017; 8(2): 103-113
URL: https://www.wjgnet.com/2150-5349/full/v8/i2/103.htm
DOI: https://dx.doi.org/10.4292/wjgpt.v8.i2.103