Plecanatide-mediated activation of guanylate cyclase-C suppresses inflammation-induced colorectal carcinogenesis in Apc+/Min-FCCC mice

Figure 2 Treatment with plecanatide inhibits inflammation-associated colonic dysplasia in dextran sodium sulfate-treated Apc^+/Min-FCCC mice. Analyses revealed the number of pathologically confirmed polypoid (A), flat (B), indeterminate (C) and total (D) dysplasias within the colon of DSS-treated mice following administration (7 wk) of either control diet or diet supplemented with varying doses of plecanatide (n = 23/group). Wilcoxon 2-sample test and analysis of variance (ANOVA) were used to compare the multiplicity of dysplasias in independent groups. A P value ≤ 0.05 was considered statistically significant. DSS: Dextran sodium sulfate