Pathogenic mechanisms of pancreatitis

Figure 2 Pathogenesis of pancreatitis. Diagrammatic representation of the onset of pancreatitis by damaged pancreatic acinar cells which in turn activates quiescent pancreatic stellate cells (PSCs) to become activated PSCs and promote subsequent fibrosis of pancreas. TNF-α: Tumor necrosis factor-α; TGF-β: Transforming growth factor-β; PDGF: Platelet-derived growth factor; IL: Interleukin.