Clinical significance and management of Barrett’s esophagus with epithelial changes indefinite for dysplasia

Figure 1 Examples of Barrett’s esophagus with epithelial changes, indefinite for dysplasia. A: This esophageal biopsy shows inflamed BE with moderate architectural complexity, more extensive nuclear stratification, diminished or absent mucus production, increased cytoplasmic basophilia, resembling low-grade dysplasia, but there is presence of marked inflammation (HE stain, × 40). This biopsy is best interpreted as indefinite for dysplasia; B: This tangentially sectioned esophageal biopsy shows foci of glands with enlarged and hyperchromatic nuclei (HE stain, × 100). Because of the lack of surface epithelium as a result of tangential section, this biopsy is best interpreted as indefinite for dysplasia. BE: Barrett’s esophagus.