Disaccharidase activity in children undergoing esophagogastroduodenoscopy: A systematic review

Table 2 Description of 8 studies examining intestinal disaccharides in children undergoing esophagogastroduodenoscopy with sample size between 50 and 200

Ref.	Histology; association between histology and disaccharidase activity	Other underlying condition	Sample size, % male	Age range, mean	Ethnicity	Lactase (μmol/min per gram) mean	Sucrase (μmol/min per gram) mean	Maltase (μmol/min per gram) mean	Palatinase (μmol/min per gram) mean
Disaccharidase deficiency in pediatric patients with celiac disease and intact villi (2011) Mones et al[21] United States	Increased lymphocytes and crypt hypertrophy; Association not reported	Celiac disease	51 CD: 25, 54% Control: 26, 50%	Ranges not reported, CD: 11.3 yr Control: 12.3 yr	Not reported	11.6	34.1	104.7	7.25
Disaccharidase activities, jeujunal morphology, and carbohydrate tolerance in children with chronic diarrhea (1985) Calvin et al[14] United States	Villous atrophy; Association present for lactase, sucrase, and maltase	Chronic Diarrhea	88, sex not reported	1-16 yr, 25 mo	Not reported	23.7	56.3	214.6	Not reported
Brush border enzyme activities in relation to histological lesion in pediatric celiac disease (2008) Prasad et al[16] India	Villous atrophy; Association present for lactase, sucrase, and maltase	GERD, celiac disease	GERD: 29, 62.09% CD: 71, 60.56%	CD: 15 mo-14 yr, 6.0 yr Control: 18 mo-14 yr, 6.2 yr	North Indian	15.7	30.7	62.3	Not reported
Activity of duodenal disaccharidases in relation to normal and abnormal mucosal morphology (1990) Langman et al[15] Australia	Mucosal inflammation and villous atrophy; Association present for lactase, sucrase, and maltase	Suspected celiac disease, giardiasis, diarrhea, weight loss, abdominal pain, low folate concentrations	100, 41%	7-76 yr, Four patients under 15 yr, data is from all pts including adults 39 yr	98 Caucasian (98%) 1 African (1%) 1 Indian (1%)	5.7	16	28.5	Not reported
Glucoamylase and dissacharidase activities in normal subjectsand in patients with mucosal injury of the small intestine (1980) Lebenthal et al[29] United States	Villous atrophy; Association present for lactase, sucrase, maltase, and palatinase	Chronic diarrhea, failure to thrive	124, sex not reported	1 mo-18 yr, mean not reported	Not reported	19.7	42.4	141	10.8
Disaccharidase activity in infants and comparison based on symptoms and histological changes (2007) Tori et al[11] United States	Villous atrophy; Association present for lactase, sucrase, maltase, and palatinase	Diarrhea, failure to thrive	131, 57%	20 d-364 d, 180 d	111 Caucasian (85%) 14 African (11%)	29.2	42.1	138.2	10
Correlation of Lactase activity, lactose tolerance and milk consumption in different age groups (1975) Lebenthal et al[10] United Kingdom	No abnormalities	Failure to thrive with no organic cause, irritable colon syndrome	160 sex not reported	6 wk-50 yr, mean not reported	6 Other (4%) Caucasian	29.8	56.2	189.6	15.5
Intestinal Disaccharidase activity in patients with autism (2011) Kushak et al[20] United States	Mucosal inflammation (6%); Association present for lactase.	Autism (abdominal pain, flatulence, constipation, vomiting, weight loss, food allergy, suspected GERD)	199, 82.40%	22 mo-28 yr, 5.75 yr	195 Caucasian (98%) 2 Asian (1%) 2 Indian (1%)	14.7	45.6	209.2	Not reported

GERD: Gastroesophageal reflux disease.