Effect of electrical stimulation of the lower esophageal sphincter in gastroesophageal reflux disease patients refractory to proton pump inhibitors

doi:10.4292/wjgpt.v7.i1.145

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World Journal of Gastrointestinal Pharmacology and Therapeutics

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2150-5349

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pharmacol Ther. Feb 6, 2016; 7(1): 145-155
Published online Feb 6, 2016. doi: 10.4292/wjgpt.v7.i1.145

Table 2 Severity of heartburn and regurgitation was significantly improved in both groups during the study, with significant difference between the 2 subgroups

	Incomplete responders				Complete responders
	Visit interval(subject number)	Median (IQR)	P value		Visit interval(subject number)	Median (IQR)	P value
	Visit interval(subject number)	Median (IQR)	Baseline ON-PPI	Baseline OFF-PPI	Visit interval(subject number)	Median (IQR)	Baseline ON-PPI	Baseline OFF-PPI
Percent diary days with heartburn severity	Baseline OFF PPI (14)				Baseline OFF PPI (6)
	12 mo (15)			< 0.001	12 mo (6)			0.03
	24 mo (12)			< 0.001	24 mo (7)			0.03
None	Baseline OFF PPI (14)	0 (0-10)			Baseline OFF PPI (6)	0 (0-14)
	12 mo (15)	88 (42-100)			12 mo (6)	83 (54-100)
	24 mo (12)	86 (73-100)			24 mo (7)	79 (32-93)
Mild	Baseline OFF PPI (14)	19 (14-29)			Baseline OFF PPI (6)	14 (0-14)
	12 mo (15)	0 (0-32)			12 mo (6)	0 (0-25)
	24 mo (12)	7 (0-14)			24 mo (7)	7 (0-18)
Moderate	Baseline OFF PPI (14)	46 (31-66)			Baseline OFF PPI (6)	62 (46-68)
	12 mo (15)	0 (0-7)			12 mo (6)	0 (0-11)
	24 mo (12)	0 (0-7)			24 mo (7)	7 (0-29)
	Baseline OFF PPI (14)	11 (0-29)			Baseline OFF PPI (6)	8 (4-21)
Severe	12 mo (15)	0 (0-0)			12 mo (6)	0 (0-1)
	24 mo (12)	0 (0-0)			24 mo (7)	0 (0-4)
% Diary days with regurgitation severity	Baseline OFF PPI (14)				Baseline OFF PPI (6)		0.03	0.03
	12 mo (15)			< 0.003	12 mo (6)
	24 mo (12)			< 0.03	24 mo (7)
None	Baseline OFF PPI (14)	35 (7-70)			Baseline OFF PPI (6)	4 (0-8)
	12 mo (15)	100 (100-100)			12 mo (6)	100 (100-100)
	24 mo (12)	100 (95-100)			24 mo (7)	100 (86-100)
Mild	Baseline OFF PPI (14)	8 (7-20)			Baseline OFF PPI (6)	19 (9-54)
	12 mo (15)	0 (0-0)			12 mo (6)	0 (0-0)
	24 mo (12)	0 (0-0)			24 mo (7)	0 (0-4)
Moderate	Baseline OFF PPI (14)	30 (4-57)			Baseline OFF PPI (6)	29 (11-46)
	12 mo (15)	0 (0-0)			12 mo (6)	0 (0-0)
	24 mo (12)	0 (0-0)			24 mo (7)	0 (0-4)
	Baseline OFF PPI (14)	0 (0-21)			Baseline OFF PPI (6)	0 (0-16)
Severe	12 mo (15)	0 (0-0)			12 mo (6)	0 (0-0)
	24 mo (12)				24 mo (7)	0 (0-0)

PPI: Proton pump inhibitor.

Citation: Soffer E, Rodríguez L, Rodriguez P, Gómez B, Neto MG, Crowell MD. Effect of electrical stimulation of the lower esophageal sphincter in gastroesophageal reflux disease patients refractory to proton pump inhibitors. World J Gastrointest Pharmacol Ther 2016; 7(1): 145-155
URL: https://www.wjgnet.com/2150-5349/full/v7/i1/145.htm
DOI: https://dx.doi.org/10.4292/wjgpt.v7.i1.145