Present state and future challenges in pediatric abdominal pain therapeutics research: Looking beyond the forest

Table 2 Chronological list of placebo controlled drug trials for functional gastrointestinal disorders related to abdominal pain in children and adolescents, including summary of treatment, sample size, and outcome

Ref.	Treatment	Diagnosis	Sample size (enrolled/completed)	Superior to placebo for pain relief
Symon and Russell[44] (1995)	Pitotifen	Abdominal migraine	16/14	Yes
Kline et al[45] (2001)	Enteric coated peppermint oil capsules	Irritable bowel syndrome	50/42	Yes
See et al[46] (2001)	Famotidine	Abdominal pain and dyspepsia	25/25	Yes
Friesen et al[47] (2004)	Montelukast	FD with duodenal eosinophilia	40/37	Yes
Bahar et al[48] (2008)	Amitriptyline	Irritable bowel syndrome	35/33	Yes
Sadeghian et al[49] (2008)	Cyproheptadine	Functional abdominal pain	36/28	Yes
Saps et al[50] (2009)	Amitriptyline	FD, irritable bowel syndrome, and functional abdominal pain	90/83	No
Pourmoghaddas et al[51] (2014)	Mebeverine	Functional abdominal pain	115/87	No