Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a-/- mice

Table 3 Attenuation of inflammatory gene expression in mdr1a^-/- mice treated orally with an extract from Prunella vulgaris

		Fold change compared to vehicle-treated mdr1a-/- micea
Gene	Pathway affiliation	FVBWT vehicle healthy	mdr1a-/-P. vulgaris healthy	mdr1a-/-P. vulgaris colitic
Ccl2	NF-κB, LDL	-7.3	-3.4	-1.1
Cxcl1	NF-κB	-11.3	-7.2	-1.0
Cxcl9	NF-κB, Jak/Stat	-23.9	-4.2	-1.1
Icam1	NF-κB, Phospholipase C	-3.2	-1.2	1.8
Il1a	NF-κB	-13.4	-8.0	1.3
Mmp10	NF-κB, Jak/Stat	-6.6	-8.5	1.2
TNFα	NF-κB	-10.2	-2.6	1.2
Vcam1	NF-κB, Phospholipase C, LDL	-3.8	-2.0	1.2
Ccl20	NF-κB	-3.6	-2.0	1.4
Il2	NF-κB, NFAT, Calcium, PKC	-3.7	-2.2	-1.5

^aA negative value indicates that there was a lower level of gene expression when compared to the level of gene expression in vehicle-treated mdr1a^-/- mice that developed severe colitis. P. vulgaris: Prunella vulgaris.