Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a-/- mice

Table 2 Assessment of selected cytokines in the serum of mice

Cytokine/chemokine	FVBWT vehicle (n = 6)	mdr1a-/- vehicle (n = 16)	mdr1a-/-P. vulgaris (n = 13)
G-CSF	140.1 ± 15b	9694.0 ± 2563	4597.0 ± 1931
GM-CSF	ND	21.1 ± 11	1.5 ± 1
IL-9	77.9 ± 27a	200.1 ± 38	117.8 ± 14
IL-10	NDb	19.4 ± 4	4.6 ± 2ad
IL-17	4 ± 2	16 ± 4	1 ± 1
CXCL10	8.4 ± 5b	724.3 ± 136	397.2 ± 85
KC	69.5 ± 24b	527.1 ± 119	253.4 ± 58
CXCL9	108.7 ± 37b	3901.0 ± 858	1319.0 ± 277c
TNFα	9.3 ± 0.1b	14.8 ± 1	9.9 ± 3c

Serum samples were collected at the time mice were euthanized and analyzed as described in Materials and Methods. Average values (pg/mL serum) are shown here ± standard error of the mean except where noted.

^aP < 0.05,

^bP < 0.01 compared to mdr1a^-/- vehicle with Kruskal-Wallis test with Dunn’s multiple comparisons test.

^cP < 0.05,

^dP < 0.01 compared to mdr1a-/- vehicle with unpaired t-test with Welch’s correction. ND: Not detectable; P. vulgaris: Prunella vulgaris.