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©The Author(s) 2015.
World J Gastrointest Pharmacol Ther. Nov 6, 2015; 6(4): 223-237
Published online Nov 6, 2015. doi: 10.4292/wjgpt.v6.i4.223
Published online Nov 6, 2015. doi: 10.4292/wjgpt.v6.i4.223
Table 1 Histopathological scores of cecal tissue
Microscopic parameter | FVBWT vehicle (n = 6) | mdr1a-/- vehicle (n = 10) | mdr1a-/-P. vulgaris (n = 7) |
Mucosal height (μm) | 3.5 ± 0.2a | 4.6 ± 0.2 | 3.9 ± 0.2 |
Ulceration | 0.2 ± 0.2 | 1.9 ± 0.3 | 1.2 ± 0.4 |
Inflammation | 1.3 ± 0.2b | 3.6 ± 0.2 | 2.5 ± 0.4c |
Edema | 0.7 ± 0.5a | 2.4 ± 0.3 | 0.9 ± 0.3c |
Stromal collapse (necrosis) | 0.0 ± 0.0a | 1.7 ± 0.4 | 0.5 ± 0.4 |
Gland hyperplasia | 1.2 ± 0.2b | 2.8 ± 0.2 | 2.1 ± 0.3c |
Additive cecal score | 6.9 ± 0.9b | 17.0 ± 1.2 | 11.1 ±1.5 |
Mice exhibiting cecal neutrophil infiltrate | 17%b | 100% | 38%c |
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Citation: Haarberg KM, Wymore Brand MJ, Overstreet AMC, Hauck CC, Murphy PA, Hostetter JM, Ramer-Tait AE, Wannemuehler MJ. Orally administered extract from
Prunella vulgaris attenuates spontaneous colitis in mdr1a-/- mice. World J Gastrointest Pharmacol Ther 2015; 6(4): 223-237 - URL: https://www.wjgnet.com/2150-5349/full/v6/i4/223.htm
- DOI: https://dx.doi.org/10.4292/wjgpt.v6.i4.223