Antibiotic treatment for Helicobacter pylori: Is the end coming?

Table 3 Helicobacter pylori eradication rates following first-line concomitant therapy

Country	Ref.	Publication	Treatment duration	Patients	Therapy regimen	Eradication rate (ITT)	Eradication rate (PP)
South Korea	Lim et al[104]	2013	14 d	78	Rab 20 mg bid	80.8%	81.3%
					Amo 1 g bid
					Cla 500 mg bid
					Met 500 mg bid
	Lee et al[100]	2015	7 d	170	Rab 20 mg bid	79.4%	94.4%
					Amo 1 g bid
					Cla 500 mg bid
					Met 500 mg tid
Thailand	Kongchayanun et al[188]	2012	5 d/10 d	55/55	Rab 20 mg bid	89.1%/96.4%	NA
					Amo 1 g bid
					Met 400 mg tid
					Cla 1 g qd
Singapore	Ang et al[102]	2015	10 d	153	PPI standard does	81.7%	95.4%
					Amo 1 g bid
					Cla 500 mg bid
					Met 400 mg bid
Spain	Molina-Infante et al[97]	2012	10 d	209	PPI standard does	87.0%	89.0%
					Amo 1 g bid
					Cla 500 mg bid
					Met 500 mg bid
	McNicholl et al[103]	2014	10 d	168	Ome 20 mg bid	87.0%	91.0%
					Amo 1 g bid
					Cla 500 mg bid
					Met 500 mg bid
Latin America	Greenberg et al[106]	2011	5 d	489	Lan 30 mg bid	73.6%	NA
					Amo 1 g bid
					Cla 500 mg bid
					Met 500 mg bid

ITT: Intention to treat; PP: Per protocol; NA: Not available; Lan: Lansoprazole; Amo: Amoxicillin; Cla: Clarithromycin; Met: Metronidazole; PPI: Proton pump inhibitor; Rab: Rabeprazole; Ome: Omeprazole.