Antibiotic treatment for Helicobacter pylori: Is the end coming?

Table 2 Helicobacter pylori eradication rates following first-line sequential therapy

Country	Ref.	Publication	Treatment duration	Patients	Therapy regimen	Eradication rate (ITT)	Eradication rate (PP)
South Korea	Lee et al[92]	2014	10 d	111	1st 5 d: Eso + Amo	72.1%	78.4%
					2nd 5 d: Eso + Cla + Met
	Lee et al[91]	2015	10 d	100	1st 5 d: Rab + Amo	79.0%	84.9%
					2nd 5 d: Rab + Cla + Met
China	Zhou et al[93]	2014	10 d	140	1st 5 d: Eso + Amo	72.1%	76.5%
					2nd 5 d: Eso + Cla + Tin
Qatar	Ben Chaabane et al[94]	2015	14 d	106	1st 7 d: Rab + Amo	66.0%	76.0%
					2nd 7 d: Rab + Cla + Met
Italy	Pontone et al[187]	2010	10 d	84	1st 5 d: Lan + Amo	83.3%	90.9%
					2nd 5 d: Lan + Cla + Met
Spain	Molina-Infante et al[114]	2010	10 d	115	1st 5 d: Ome + Amo	76.5%	80.8%
					2nd 5 d: Ome + Cla + Met

ITT: Intention to treat; PP: Per protocol; Lan: Lansoprazole; Amo: Amoxicillin; Cla: Clarithromycin; Met: Metronidazole; Ome: Omeprazole; Eso: Esomeprazole; Tin: Tinidazole; Rab: Rabeprazole.