Pharmaceutical management of hepatitis B and C in liver and kidney transplant recipients

doi:10.4292/wjgpt.v6.i4.105

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Nov 6, 2015 (publication date) through Jul 2, 2024

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World Journal of Gastrointestinal Pharmacology and Therapeutics

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2150-5349

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pharmacol Ther. Nov 6, 2015; 6(4): 105-110
Published online Nov 6, 2015. doi: 10.4292/wjgpt.v6.i4.105

Table 1 Recommendations for the management of hepatitis B and C infection after liver or kidney transplantation

Chronic hepatitis B	Post-liver transplantation	Prophylaxis and treatment	HBIG (for short term) plus NA¹
	Post-kidney transplantation		NAs¹
Chronic hepatitis C	Post-liver transplantation	No prophylaxis	Sofosbuvir based regimens or “3D” regimen plus RBV (for genotypes 1 and 4)
	Post-kidney transplantation		Newer direct oral antivirals plus/minus RBV (studies are ongoing)²

¹Frontline analogues are considered entecavir or tenofovir in renal proper doses (consider telbivudine in the presence of renal dysfunction);

²Interferon is contraindicated due to the high risk of allograft rejection. HBIG: Hepatitis B immune globulin; NAs: Nucleos(t)ide analogues; 3D: Paritaprevir (plus ritonavir)/ombitasvir/dasabuvir for genotype 1 and paritaprevir (plus ritonavir)/ombitasvir for genotype 4; RBV: Ribavirin.

Citation: Pipili C, Cholongitas E. Pharmaceutical management of hepatitis B and C in liver and kidney transplant recipients. World J Gastrointest Pharmacol Ther 2015; 6(4): 105-110
URL: https://www.wjgnet.com/2150-5349/full/v6/i4/105.htm
DOI: https://dx.doi.org/10.4292/wjgpt.v6.i4.105