Nociceptin effect on intestinal motility depends on opioid-receptor like-1 receptors and nitric oxide synthase co-localization

Figure 7 Effect of nociceptin (1 μmol/L) and [NPhe¹]NOC (1 μmol/L) on the spatial distribution of the excitatory junction potentials. A: A concentration-dependent reduction in excitatory junction potentials (EJP) amplitude at the different stimulation sites induced by nociceptin (10 nmol/L-1 μmol/L). Note that nociceptin caused, besides a reduction in the EJP amplitude, shortening of the distance over which the EJP can be recorded; B: [NPhe¹]NOC (1 μmol/L) had no effect on EJPs, but antagonized the effect of nociceptin (1 μmol/L).