Nociceptin effect on intestinal motility depends on opioid-receptor like-1 receptors and nitric oxide synthase co-localization

Figure 5 Effect of nociceptin (1 nmol/L-10 μmol/L) on electrically induced junction potentials. A: EJP, fIJP and sIJP for proximal colon; B: fIJP and sIJP for middle colon; C: IJP for distal colon. The last bar of each set shows the antagonizing effect of [NPhe¹]NOC (1 μmol/L). Data are mean ± SEM of n = 5-8. ^aP < 0.05; ^bP < 0.01 vs control; ^cP < 0.05 vs nociceptin alone. EJP: Excitatory junction potentials; IJP: Inhibitory junction potentials; fIJP: Fast IJP; sIJP: Slow IJP.