Aspirin, cyclooxygenase inhibition and colorectal cancer

Table 3 Clinical effects of aspirin on sporadic colorectal cancer (clinical trials)

	Rothwell et al meta analysis	Physician’s health study	Women’s health study
ASA dosage	75-1200 mg/d	325 mg per every other day	100 mg per every other day
Duration of follow up (yr)	≥ 20	10	10
Relative risk of CRC over follow up (HR)	0.76 (95%CI: 0.60-0.96)	1.03 (95%CI: 0.83-1.28)	0.97 (95%CI: 0.77-0.24)

Comparison of findings from meta-analysis performed by Rothwell et al[13] and incidence data of Physician’s Health Study and Women’s Health Study studies[13,15,16]. CRC: Colorectal cancer; ASA: Aspirin.