Clinical update for the diagnosis and treatment of Clostridium difficile infection

doi:10.4292/wjgpt.v5.i1.1

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Feb 6, 2014 (publication date) through Dec 28, 2024

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World Journal of Gastrointestinal Pharmacology and Therapeutics

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2150-5349

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pharmacol Ther. Feb 6, 2014; 5(1): 1-26
Published online Feb 6, 2014. doi: 10.4292/wjgpt.v5.i1.1

Table 1 Characteristics of tests for Clostridium difficile infections

	Sensit-ivity	Detects toxin in stool	Time totest completion	Cost	Availability	Standalonetest
EIA Toxin A/B	++	Yes	h	+	++++	Yes
GDH¹	++++	No⁵	h	+	++++	No
PCR²	+++	No⁶	h	++++	+++	Yes
TC³	+++++	No⁶	d	+++	+⁷	Yes
CCCNA⁴	+++	Yes	d	+++	+⁷	Yes

¹Glutamate dehydrogenase;

²Polymerase chain reaction;

³Toxigenic culture;

⁴Cell culture cytotoxicity neutralization assay;

⁵Detects presence of Clostridium difficile (C. difficile I) only, but not toxin producing capability, requires confirmatory testing;

⁶Detects toxin producing C. difficile, but not toxin in stool, false (+) in asymptomatic carriers;

⁷Only available in research laboratory. EIA: Enzyme immunoassay; GDH: Glutamate dehydrogenase; PCR: Polymerase chain reaction; TC: Toxigenic culture; CCCNA: Cell culture cytotoxicity neutralization assay.

Citation: IV ECO, III ECO, Johnson DA. Clinical update for the diagnosis and treatment of Clostridium difficile infection. World J Gastrointest Pharmacol Ther 2014; 5(1): 1-26
URL: https://www.wjgnet.com/2150-5349/full/v5/i1/1.htm
DOI: https://dx.doi.org/10.4292/wjgpt.v5.i1.1