Association of ITPA polymorphism with outcomes of peginterferon-&alpha; plus ribavirin combination therapy

doi:10.4292/wjgpt.v4.i3.54

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World Journal of Gastrointestinal Pharmacology and Therapeutics

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pharmacol Ther. Aug 6, 2013; 4(3): 54-60
Published online Aug 6, 2013. doi: 10.4292/wjgpt.v4.i3.54

Table 3 Virological response according to classification by inosine triphosphatase and interleukin 28B single-nucleotide polymorphisms n (%)

Virological response	IL28B: TT		IL28B: TG + GG
Virological response	CA + AA (n = 29)¹	CC (n = 53)¹	CA + AA (n = 8)¹	CC (n = 30)¹
RVR	3 (10.3)	10 (18.9)	0 (0.0)	4 (13.3)
RVR + EVR	18 (62.1)	35 (66.0)	1 (12.5)	8 (26.6)
SVR	13 (44.8)	29 (54.7)	2 (25.0)	8 (26.6)

¹Inosine triphosphatase (ITPA). SVR: Sustained virological response; RVR: Rapid virological response; EVR: Early virological response; IL28B: Interleukin 28B.

Citation: Fujino T, Aoyagi Y, Takahashi M, Yada R, Yamamoto N, Ohishi Y, Nishiura A, Kohjima M, Yoshimoto T, Fukuizumi K, Nakashima M, Kato M, Kotoh K, Nakamuta M, Enjoji M. Association of ITPA polymorphism with outcomes of peginterferon-α plus ribavirin combination therapy. World J Gastrointest Pharmacol Ther 2013; 4(3): 54-60
URL: https://www.wjgnet.com/2150-5349/full/v4/i3/54.htm
DOI: https://dx.doi.org/10.4292/wjgpt.v4.i3.54