Antifibrotic effect of heparin on liver fibrosis model in rats

Figure 4 Photomicrograph of liver sections. Normal control (normal arrangement of central vein and intact parenchyma) (A) and carbon tetrachloride control rats development of large septa of connective tissue flowing together and penetrating into the parenchyma, initiation of fibrous septa formation (B) and progressive septa formation which have a tendency to develop nodules of the liver architecture with loss of the structure of the hepatic lobules, seen in (C). Silymarin treated rats showing progressive breakage of fibrous septa (D) and mild degree of fibrolysis with lymphocytic infiltration (E), Heparin treated rats showing progressive breakage of fibrous septa (F) and moderate degree of fibrolysis with lymphocytic infiltration (G), Silymarin and Heparin treated rats showing progressive breakage and almost dissolution of fibrous septa (H) and severe degree of fibrolysis with lymphocytic infiltration (I). Control treated rats showing normal arrangement of central vein and intact parenchymal cells (J).