Antifibrotic effect of heparin on liver fibrosis model in rats

Table 2 Histopathological scoring of liver sections of control and treated animals

Parameters	Normal control	CCl4 control	Silymarin (100 mg/kg)	Heparin (2000 IU/kg)	Silymarin 100 mg/kg and heparin 2000 IU/kg treated (combination) group	Control treated
Degree (area) of fibrosis	0	4	3	2	1	0
Percentage area of fibrosis	Fibrosis not observed	58	24.7dA	15.7dA,aB	12.9dA,bC	Fibrosis not observed

Data represented as scores. Scoring was performed as 0 representing normal liver histology (no area/absence of fibrotic area). Scoring 1, 2, 3, 4 represent mild, moderate, high and severe degree (area) of fibrosis respectively. ^aP < 0.05; ^bP <0.01; ^dP < 0.001. A: CCl₄ control vs treatment group; B: Silymarin vs heparin 2000 IU/kg treated group; C: Silymarin vs silymarin 100 mg/kg and heparin 2000 IU/kg treated (combination) group.