Accelerated infliximab infusions for inflammatory bowel disease improve effectiveness

Table 3 Data for each individual study participant

No	Patient	Age (yr)	BMI	Dose1	Date		Diagnose	Diagnosis
					90 min infusion	60 min infusion3
1	Male: Caucasian	37	170lbs (77 kg)BMI = 21.83 kg/m2	22 infusions5 mg/kg per 8 wk	12/16/2011	02/20/2012	Ulcerative colitis	Tylenol 650 mgClaritin 10 mgSolucortef 100 mg
2	Male: Caucasian	56	202lbs (91 kg)BMI = 28.98 kg/m2	13 infusions7.5 mg/kg per 8 wk	04/02/2012		Crohn's disease
3	Male: Caucasian	39	146lbs (66 kg)BMI = 19.80 kg/m2	50 infusions10 mg/kg per 7 wk	12/19/2011	02/09/201203/29/2012	Crohn's disease	Hydrocortisone 100 mg
4NI	Female: African-American2	50	198lbs (89 kg)BMI = 31.01 kg/m2	22 infusions5 mg/kg per 7 wkHb = 12.3 g/dL			Crohn's disease
5	Male: Caucasian	28	203lbs (92 kg)BMI = 29.17 kg/m2	38 infusions5 mg/kgper 8 wk	09/27/2011	11/22/201101/23/201203/20/2012	Crohn's disease
6	Male: Caucasian	30	115lbs (52 kg)BMI = 15.60 kg/m2	6 infusions5 mg/kg per 8 wk			Crohn's disease
7	Female: Caucasian	53	300lbs (136.5 kg)BMI = 57.78 kg/m2	42 infusions5 mg/kg per 8wk	08/08/2011	10/11/201112/21/201102/13/2012	Crohn's disease (fistulizing)
8	Female: CaucasianMoved to Germany Dec 2011	21	121lbs (55 kg)BMI = 22.18 kg/m2	12 infusions5 mg/kg per 8wk	08/22/2011	10/17/201112/12/2011	Crohn's disease
9	Male: Caucasian	50	179lbs (81 kg)BMI = 27.25 kg/m2	8 infusions5 mg/kg per 6 wk	08/23/2011	10/04/201111/15/201112/27/201102/07/201203/21/2012	Crohn's disease
10	Male: Caucasian	47	195.8lbs (89 kg)BMI = 28.96 kg/m2	15 infusions10 mg/kg per 6 wk	11/08/2011	12/27/201102/06/201203/21/2012	Crohn's disease
11	Female: Caucasian	58	157lbs (71 kg)BMI = 23.87 kg/m2	62 infusions7.5 mg/kg per 7 wk	11/07/201112/29/201102/03/2012	04/02/2012	Crohn's disease
12	Female: CaucasianMoved to another hospital	55	200lbs (90 kg)BMI = 34.16 kg/m2	50 infusions7.5 mg/kg per 8 wk	09/26/2011	11/21/2011	Crohn's disease
13	Male: Caucasian	29	154lbs (70 kg)BMI = 21.50 kg/m2	40 infusions5 mg/kg 400 mg per 6 wkHb = 15.6g/dL	01/03/2012	02/14/201203/30/2012	Crohn's disease
14	Female: Caucasian	36	248lbs (113 kg)BMI = 35.87 kg/m2	16 infusions5 mg/kg600-7.5 mg/kg shortened infusion D/C	09/02/201110/28/2011Normal infusion time01/27/2012 (after dose increase)	03/23/2012	Ulcerative colitis
15	Female: Caucasian	34	167lbs (76 kg)BMI = 29.80 kg/m2	9 infusions5 mg/kg400 mg per 6-8wkHb = 12.1g/dL	07/28/2011	09/16/201111/02/201112/20/201102/09/201203/22/2012	Crohn's disease
16	Female: Caucasian	54	121lbs (54 kg)BMI = 20.14 kg/m2	48 infusions5 mg/kg per 8 wk	03/05/2012		Crohn's disease
17	Female:African-American	68	191lbs (87 kg)BMI = 33.71 kg/m2	30 infusions 10 mg/kg per 4 wk	11/23/2011	12/22/201101/16/201202/17/201203/16/2012	Crohn's disease
18	Female: Caucasian	25	146lbs (66 kg)BMI = 22.87 kg/m2	Since 20055 mg/kg per 8 wk	01/05/201203/01/2012		Crohn's disease
19	Female: Caucasian	56	145lbs (66 kg)BMI = 22.87 kg/m2	51 infusions10 mg/kg per 5 wk	10/21/2011	12/02/201201/13/201202/17/201203/30/2012	Crohn's disease
20	Female: Caucasian	26	143lbs (65 kg)BMI = 23.85 kg/m2	10 infusions5 mg/kg per 7 wk	07/25/2011	09/23/201111/10/201101/05/201202/23/2012	Crohn's disease
21	Male: Caucasian	47	199lbs (90 kg)BMI = 22.75 kg/m2	48 infusions10 mg/kg per 6 wk	12/20/2011	01/31/201202/12/2012	Ulcerative colitis
22	Female: Caucasian	36	232lbs (105 kg)BMI = 35.28 kg/m2	5 infusions10 mg/kg,1100 mg in 500 mL per 6 wk	01/13/201202/24/2012	04/06/2012	Crohn’s disease
23	Male: Caucasian	21	202 lbs (91 kg)BMI = 27.40 kg/m2	4 infusions5 mg/kg per 8 wk	01/23/2012	03/21/2012	Crohn’s disease
24	Female: Caucasian	41	126lbs (57.5 kg)BMI = 19.86 kg/m2	14 infusions10 mg/kg per 8 wk	02/22/2012	04/12/2004	Crohn’s disease
25	Male: CaucasianTransferred receives remicade locally (01/31/12)	34	212lbs (96.8 kg)BMI = 32.46 kg/m2	24 infusions5 mg/kg per 8 wk	08/11/2011	10/07/201112/02/2011	Ulcerative colitis
26	Male: Caucasian	41	196lbs (88 kg)BMI = 32.62 kg/m2	21 infusions10 mg/kg per 6 wk	04/04/2012		Crohn’s disease
27	Male: Caucasian	63	176lbs (80 kg)BMI = 26.76 kg/m2	61 infusions5 mg/kg 400 mg	09/08/2011	11/29/201101/27/201203/14/2012	Crohn’s disease
28	Male: Caucasian	38	149lbs (67.5 kg)BMI = 22.00 kg/m2	10 infusions10 mg/kg per 6 wk	12/08/2011	01/20/201203/06/2012	Crohn’s disease
29	Female: Caucasian	42	259lbs (117.5 kg)BMI = 41.80 kg/m2	46 infusions10 mg/kg1200 mg in 500 mL	02/13/2012	04/02/2012	Crohn’s disease
30	Male: Caucasian	40	192LBS (87 kg)BMI = 27.55 kg/m2	65 infusions7.5 mg/kg per 8 wk`	12/13/2011	02/07/2012	Crohn’s disease
32	Male: Caucasian	49	154LBS (70 kg)BMI = 23.42 kg/m2	49 infusions10 mg/kg700 mg per 8wk	12/19/2011	02/10/2012	Crohn’s disease
33	Male: Caucasian	23	131lbs (59.5 kg)BMI = 18.83 kg/m2	15 infusions10 mg/kg per 8 wk	01/11/2012	03/09/2012	Ulcerative colitis
34	Male: Caucasian	26	208lbs (94.5 kg)BMI = 26.71	7 infusions5 mg/kg per 8 wk	09/12/2011	11/07/201101/03/201203/27/2012	Crohn’s disease
35	Female: African-American	24	129lbs (58.5 kg)BMI = 22.14 kg/m2	11 infusions7.5 mg/kg per 8 wkHb = 13.1 g/dL	01/23/2012	03/20/2012	Crohn’s disease
36	Male: Caucasian	31	170lbs (77 kg)BMI = 23.11 kg/m2	13 infusions5 mg/kg per 8 wk Normal infusion on 02/21 because of dose increase: 600 mg	11/14/2011	01/16/2012	Crohn’s disease
37	Male: African-American	45	267lbs (121 kg)BMI = 40.60 kg/m2	27 infusions10 mg/kg1200 mg in 500 mL per 7 wk	12/15/201102/15/201204/05/2012		Crohn’s disease
38	Male: Caucasian	89	184lbs (83.5 kg)BMI = 27.17 kg/m2	22 infusions5 mg/kg per 8 wk	07/21/2011	09/15/201111/03/201112/29/201102/23/2012	Crohn’s disease
39	Male: Caucasian	46	181lbs (82 kg)BMI = 22.62 kg/m2	24 infusions10 mg/kg per 5 wk	11/29/2011	01/10/201202/14/201203/20/2012	Crohn’s disease
40	Male: Caucasian	58	167lbs (76 kg)BMI = 27.79 kg/m2	19 infusions5 mg/kg per 8 wk	09/12/2011	11/07/201101/09/201203/05/2012	Ulcerative colitis
41	Male: Caucasian	72	169lbs (77 kg)BMI = 25.81 kg/m2	23 infusions 10 mg/kg per 7 wk	11/19/2011	01/06/201202/24/2012	Ulcerative colitis
42	Female: Caucasian	48	128lbs (58 kg)BMI = 22.32 kg/m2	54 infusions5 mg/kg per 6 wk	09/30/2011	11/23/201101/17/201203/23/2012	Crohn’s disease
43	Caucasian30 yr old	30	264lbs (120 kg)BMI = 35.88 kg/m2	44 infusions5 mg/kg per 8 wk	08/04/2011	09/29/201111/28/201101/23/201203/19/2012	Crohn’s disease
44	Female:Caucasian	44	138lbs (63 kg)BMI = 21.7 kg/m2	54 infusions10 mg/kg per 5 wk	01/26/2012	03/01/201204/05/2012	Crohn’s disease
45	Male: Caucasian	28	205lbs (93 kg)BMI = 27.80 kg/m2	10 infusions5 mg/kg per 8 wk	01/26/2012	03/21/2012	Ulcerative colitis
46	Male: African-American	43	277lbs (103 kg)BMI = 36.65 kg/m2	5 infusions5 mg/kg per 8 wk	08/19/2011	10/10/201112/05/201101/18/201202/27/2012	Crohn’s disease
47	Female: Caucasian	50	202lbs (92 kg)BMI = 34.81 kg/m2	7 infusions5 mg/kg per 6 wk	07/21/2011	09/01/201110/10/201111/21/201112/29/201102/06/201203/19/2012	Ulcerative colitis

¹Dose + numbers of remicade treatments at the time of the 1st shortened infusion + infusion frequency;

²After initial accept, the patient changed her mind and withdrew;

³1st 60 min infusion + subsequent 60 min. NI: Not included; BMI: Body mass index.