Prevention of hepatitis C recurrence after liver transplantation: An update

Table 1 Outcome of hepatitis C virus liver transplanted patients treated with cyclosporine or tacrolimus-based immunosuppression in studies including protocol liver biopsie

Ref.	Time of biopsy (yr)	CyA-based regime	Tac-based regime	P value
Gane et al[142]	At 1 and 51	No hepatitis 12/109	No hepatitis   3/21	0.1
		Mild chronic hepatitis 59/109	Mild chronic hepatitis 11/21
		Moderate chronic hepatitis  30/109	Moderate chronic hepatitis  5/21
		Cirrhosis  8/109	Cirrhosis 2/21
Testa et al[143]	1	Evidence of recurrence 72/156	Evidence of recurrence  10/18	0.4
Berenguer et al[144]	1	F0   16/44	F0 17/46	NS
		F1  16/44	F1 15/46
		F3  8/44	F3 9/46
		F4  4/44	F4 5/46
Berenguer et al[37]	1	F = 3-4   27/90	F = 2-3 22/91	0.37
	≈ 2	F = 3-4 42/110	F = 3-4 36/97	0.8

¹It is not clearly specified in the paper when liver biopsies have been performed. CyA: Cyclosporine; Tac: Tacrolimus; NS: Not significant.