Protective effects of long term antiplatelet and anticoagulant therapy in hospitalized patients with inflammatory bowel disease

Table 3 Results of multivariate regression analysis after adjusting for confounders

Outcome	Unadjusted OR/coefficient (95%CI)	P value	Adjusted OR/coefficient (95%CI)	P value
Mortality (OR)
Antiplatelet	1.55 (0.93-2.60)	0.09	0.40 (0.23-0.70)	0.001
Anticoagulant	2.27 (1.36-3.80)	0.002	0.41 (0.22-0.75)	0.004
Antiplatelet and anticoagulant	2.74 (0.87-8.67)	0.085	0.23 (0.05-1.01)	0.052
LOS days (coefficient)
Antiplatelet	0.096 (-0.06-0.25)	0.249	-0.46 (-0.63 to -0.28)	< 0.001
Anticoagulant	0.96 (0.71-1.20)	0.000	-0.502 (-0.78 to -0.22)	< 0.001
Antiplatelet and anticoagulant	0.698 (0.06-1.32)	0.030	-0.95 (-1.62 to -0.27)	< 0.001
AKI (OR)
Antiplatelet	2.43 (2.21-2.66)	< 0.001	0.95 (0.85-1.05)	0.354
Anticoagulant	2.26 (2.02-2.53)	< 0.001	0.99 (0.86-1.14)	0.942
Antiplatelet and anticoagulant	3.38 (2.66-4.31)	< 0.001	0.92 (0.69-1.22)	0.586
Sepsis (OR)
Antiplatelet	0.63 (0.47-0.84)	0.002	0.78 (0.57-1.06)	0.117
Anticoagulant	0.73 (0.52-1.00)	0.057	0.77 (0.54-1.10)	0.154
Antiplatelet and anticoagulant	0.62 (0.25-1.48)	0.279	0.78 (0.32-1.94)	0.586
Shock (OR)
Antiplatelet	1.76 (1.29-2.39)	< 0.001	0.75 (0.53-1.05)	0.103
Anticoagulant	2.24 (1.62-3.09)	< 0.001	0.64 (0.43-0.94)	0.025
Antiplatelet and anticoagulant	6.68 (4.14-10.76)	< 0.001	1.52 (0.88-2.63)	0.129
TPN (OR)
Antiplatelet	0.7 (0.54-0.92)	0.01	0.76 (0.57-1.01)	0.064
Anticoagulant	1.5 (1.21-1.87)	< 0.001	1.07 (0.83-1.40)	0.569
Antiplatelet and anticoagulant	1.23 (0.64-2.33)	0.522	1.05 (0.53-2.077)	0.877
Lower GI bleed (OR)
Antiplatelet	1.31 (1.10-1.55)	0.002	1.05 (0.87-1.26)	0.578
Anticoagulant	1.79 (1.50-2.14)	< 0.001	1.34 (1.09-1.65)	0.004
Antiplatelet and anticoagulant	2.29 (1.58-3.40)	< 0.001	1.56 (1.03-2.37)	0.035
Non-variceal upper GI bleed (OR)
Antiplatelet	1.18 (0.84-1.66)	0.325	1.13 (0.78-1.65)	0.505
Anticoagulant	1.29 (0.87-1.91)	0.189	1.03 (0.64-1.64)	0.891
Antiplatelet and anticoagulant	1.86 (0.82-4.18)	0.132	1.47 (0.62-3.46)	0.376
Colonoscopy (OR)
Antiplatelet	1.26 (1.17-1.36)	< 0.001	1.16 (1.07-1.26)	< 0.001
Anticoagulant	1.14 (1.04-1.26)	0.003	0.99 (0.90-1.26)	0.95
Antiplatelet and anticoagulant	1.63 (1.32-2.03)	< 0.001	1.31 (1.04-1.66)	0.019
Abdominal surgery (OR)
Antiplatelet	0.73 (0.64-0.82)	< 0.001	0.836 (0.72-0.96)	0.014
Anticoagulant	0.89 (0.78-1.02)	0.123	0.879 (0.74-1.03)	0.118
Both antiplatelet and anticoagulant	0.51 (0.33-0.79)	0.03	0.623 (0.39-0.97)	0.037
Total charge ($) (coefficient)
Antiplatelet	-822.2 (-2777-1132)	0.41	-4889 (-7126 to -2652)	< 0.001
Anticoagulant	8112 (5015-11208)	< 0.001	-7094 (-10979 to -3209)	< 0.001
Antiplatelet and anticoagulant	3768 (-3105-10643)	0.283	-11546 (-19475 to -3617)	< 0.001
Discharge to home or home health care (OR)
Antiplatelet	0.57 (0.51-0.63)	< 0.0001	1.23 (1.10-1.37)	< 0.001
Anticoagulant	0.50 (0.44-0.56)	< 0.0001	1.32 (1.14-1.15)	< 0.001
Antiplatelet and anticoagulant	0.37 (0.28-0.48)	< 0.0001	1.47 (1.07-2.01)	0.015
Discharge to short term hospital (OR)
Antiplatelet	0.66 (0.47-0.92)	0.015	0.56 (0.39-0.81)	0.02
Anticoagulant	1.10 (0.81-1.49)	0.535	0.84 (0.59-1.12)	0.362
Antiplatelet and anticoagulant	1.12 (0.53-2.38)	0.756	0.76 (0.33-1.74)	0.521
Discharge to SNF or other facility (OR)
Antiplatelet	3.42 (0.05-3.08)	< 0.001	0.94 (0.83-1.07)	0.403
Anticoagulant	3.40 (2.96-3.92)	< 0.001	0.80 (0.66-0.95)	0.016
Antiplatelet and anticoagulant	5.26 (3.93-7.05)	< 0.001	0.78 (0.55-1.10)	0.169

OR: Odds ratio; LOS: Length of stay; TPN: Total parenteral nutrition; AKI: Acute kidney injury; GI: Gastrointestinal; SNF: Skilled nursing facility.