Therapeutics involved in managing initial and recurrent Clostridium difficile infection: An updated literature review

Table 1 Treatment of recurrent Clostridium difficile infection in adults

Episode	Treatment modality
First recurrence	Vancomycin 125 mg orally 4 times a day for 10 days
	Fidaxomicin 200 mg orally 2 times a day for 10 days
	Adjunctive therapy: Bezlotoxumab 10 mg/kg IV one time dose
Second recurrence	Tapered or pulsed vancomycin regimen
	Vancomycin 125 mg orally 4 times a day for 10 days, then rifaximin 400 mg three times daily for 20 days
	Fidaxomicin 200 mg orally 2 times a day for 10 days
	Adjunctive therapy: Bezlotoxumab 10 mg/kg IV one time dose
Third or more recurrence	Fecal microbiota transplant
	Adjunctive therapy: Bezlotoxumab 10 mg/kg IV one time dose