Efficacy and tolerability of chitin-glucan combined with simethicone (GASTRAP® DIRECT) in irritable bowel syndrome: A prospective, open-label, multicenter study

doi:10.4292/wjgpt.v15.i3.90757

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May 28, 2024 (publication date) through Dec 28, 2024

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World Journal of Gastrointestinal Pharmacology and Therapeutics

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World J Gastrointest Pharmacol Ther. May 28, 2024; 15(3): 90757
Published online May 28, 2024. doi: 10.4292/wjgpt.v15.i3.90757

Table 4 Symptom relief at week 4 of GASTRAP^® DIRECT treatment in patients with IBS having prevalent constipation, diarrhea, and mixed irritable bowel syndrome

Symptom relief at W4	IBS-C (%)	IBS-D (%)	IBS-M (%)
Abdominal pain
Unchanged	42	27	34
Relief (very much, considerable)	58 (50, 8)	73 (46, 27)	66 (48, 18)
Bloating
Unchanged	42	32	31
Relief (very much, considerable)	58 (46, 12)	68 (41, 27)	69 (53, 16)
Abdominal distension
Unchanged	46	50	39
Relief (very much, considerable)	54 (39, 15)	50 (36, 14)	61 (39, 21)

W: Weeks; IBS: Irritable bowel syndrome; IBS-C: IBS patients with prevalent constipation; IBS-D: IBS patients with prevalent diarrhea; IBS-M: IBS patients with mixed symptoms.

Citation: Talbodec N, Le Roy P, Fournier P, Lesage B, Lepoutre E, Castex F, Godchaux JM, Vandeville L, Bismuth B, Lesage X, Bayart P, Genin M, Rousseaux C, Maquet V, Modica S, Desreumaux P, Valibouze C. Efficacy and tolerability of chitin-glucan combined with simethicone (GASTRAP^® DIRECT) in irritable bowel syndrome: A prospective, open-label, multicenter study. World J Gastrointest Pharmacol Ther 2024; 15(3): 90757
URL: https://www.wjgnet.com/2150-5349/full/v15/i3/90757.htm
DOI: https://dx.doi.org/10.4292/wjgpt.v15.i3.90757