Cinnamic acid regulates the intestinal microbiome and short-chain fatty acids to treat slow transit constipation

Figure 1 Pharmacological effects of cinnamic acid on slow transit constipation mice. A: Number of fecal remnants in the colon of mice in each group (n = 8); B: Number of fecal remnants in the colon of mice in each group (n = 8); C: 24 h defecations of mice in each group (n = 8); D: Fecal water content of mice in each group (n = 8); E: Intestinal transit rate of mice in each group (n = 8). ^aP < 0.05 and ^bP < 0.01 versus the control group; ^cP < 0.05 and ^dP < 0.01 versus the slow transit constipation model group. NS: Not significant. PRU: Prucalopride; CA-low: Cinnamic acid with low dose; CA-high: Cinnamic acid with high dose.