Impact of epinephrine volume on further bleeding due to high-risk peptic ulcer disease in the combination therapy era

Table 3 Multivariable logistic regression and cox proportional hazards analyses for factors associated with further bleeding at 30 d, need for additional therapeutic interventions, and mortality at 30 d

Variable	aOR or aHR	95%CI	P value
Further bleeding at 30 d1:
Hematochezia	2.83	0.95-8.44	0.06
Creatinine (mg/dL)	1.73	1.18-2.64	< 0.01
Hypotension requiring vasopressors	7.68	2.69-24.38	< 0.001
Epinephrine volume (mL)	1.07	0.93-1.24	0.31
Need for additional therapeutic interventions1:
Admission status (in-hospital)	1.36	0.37-5.18	0.64
Hematochezia	1.49	0.43-4.90	0.52
Creatinine (mg/dL)	1.60	1.06-2.47	0.03
Hypotension requiring vasopressors	8.53	2.51-34.72	< 0.01
Epinephrine volume (mL)	1.09	0.93-1.26	0.27
Mortality at 30 d2:
Creatinine (mg/dL)	1.77	1.36-2.30	< 0.001
Hypotension requiring vasopressors	4.09	1.39-12.09	0.01

¹Logistic regression analysis.

²Cox proportional hazards analysis. Variables with P < 0.05 in univariable analysis were included in multivariable analysis. aHR: Adjusted hazard ratio; aOR: Adjusted odds ratio; BUN: Blood urea nitrogen; CI: Confidence interval.