Retrospective Cohort Study
Copyright ©The Author(s) 2020.
World J Gastrointest Pharmacol Ther. Jun 9, 2020; 11(2): 25-39
Published online Jun 9, 2020. doi: 10.4292/wjgpt.v11.i2.25
Table 1 Clinical and pathological characteristics of pancreatic ductal adenocarcinoma patients
FeatureLevelTotal cohortSubcohort
Invasive IPMNNon-IPMN associated PDACP value
Median (IQR)
Age (in yr)67.6 (60.0, 74.8)70.0 (64.1, 75.5)66.7 (59.4, 74.0)0.003
Tumor size (in cm)3.5 (2.5, 5.0)3.0 (2.0, 4.5)3.6 (2.5, 5.2)0.012
Median (95%CI)
PFS (in mo)21.0 (17.0, 27.0)NR (47.0, NR)17.0 (13.0, 22.0)< 0.001
OS (in mo)21.0 (19.0, 24.0)60.0 (28.0, 69.0)19.0 (18.0, 22.0)< 0.001
n (%)
Gender (male/female)Female243 (53.5)61 (53.0)182 (53.7)0.991
Male211 (46.5)54 (47.0)157 (46.3)
Tumor differentiationWell41 (9.0)15 (13.4)26 (7.9)0.103
Moderate271 (59.7)71 (63.4)200 (61.0)
Poor128 (28.2)26 (23.2)102 (31.1)
AJCC 8th ed staging systemT176 (16.7)32 (27.8)44 (13.0)0.003
T2202 (44.5)46 (40.0)156 (46.2)
T3166 (36.6)36 (31.3)130 (38.5)
AJCC 8th ed staging systemN0216 (47.6)69 (60.0)147 (43.4)0.004
N1181 (39.9)31 (27.0)150 (44.2)
N257 (12.6)15 (13.0)42 (12.4)
Lymphovascular invasionPositive219 (48.2)44 (38.3)175 (51.6)0.011
Negative219 (48.2)69 (60.0)150 (44.2)
Indetermi-nant16 (3.5)2 (1.7)14 (4.1)
Perineural invasionPositive366 (80.6)80 (69.6)286 (84.4)0.001
Negative82 (18.1)34 (29.6)48 (14.2)
Indetermi-nant6 (1.3)1 (0.9)5 (1.5)
Recurrence/metastasisPresent218 (48.0)43 (37.4)175 (51.6)0.015
Absent236 (52.0)72 (62.6)164 (48.4)
Splenic parenchymal invasionPresent25 (5.5)2 (1.7)23 (6.9)0.067
Absent425 (93.6)113 (98.3)312 (93.1)

  • Citation: Yin F, Saad M, Xie H, Lin J, Jackson CR, Ren B, Lawson C, Karamchandani DM, Bernabeu BQ, Jiang W, Dhir T, Zheng R, Schultz CW, Zhang D, Thomas CL, Zhang X, Lai J, Schild M, Zhang X, Liu X. Validation of American Joint Committee on Cancer 8th edition of TNM staging in resected distal pancreatic cancer. World J Gastrointest Pharmacol Ther 2020; 11(2): 25-39
  • URL: https://www.wjgnet.com/2150-5349/full/v11/i2/25.htm
  • DOI: https://dx.doi.org/10.4292/wjgpt.v11.i2.25