Copyright
©The Author(s) 2020.
World J Gastrointest Pharmacol Ther. Jun 9, 2020; 11(2): 25-39
Published online Jun 9, 2020. doi: 10.4292/wjgpt.v11.i2.25
Published online Jun 9, 2020. doi: 10.4292/wjgpt.v11.i2.25
Feature | Level | Total cohort | Subcohort | ||
Invasive IPMN | Non-IPMN associated PDAC | P value | |||
Median (IQR) | |||||
Age (in yr) | 67.6 (60.0, 74.8) | 70.0 (64.1, 75.5) | 66.7 (59.4, 74.0) | 0.003 | |
Tumor size (in cm) | 3.5 (2.5, 5.0) | 3.0 (2.0, 4.5) | 3.6 (2.5, 5.2) | 0.012 | |
Median (95%CI) | |||||
PFS (in mo) | 21.0 (17.0, 27.0) | NR (47.0, NR) | 17.0 (13.0, 22.0) | < 0.001 | |
OS (in mo) | 21.0 (19.0, 24.0) | 60.0 (28.0, 69.0) | 19.0 (18.0, 22.0) | < 0.001 | |
n (%) | |||||
Gender (male/female) | Female | 243 (53.5) | 61 (53.0) | 182 (53.7) | 0.991 |
Male | 211 (46.5) | 54 (47.0) | 157 (46.3) | ||
Tumor differentiation | Well | 41 (9.0) | 15 (13.4) | 26 (7.9) | 0.103 |
Moderate | 271 (59.7) | 71 (63.4) | 200 (61.0) | ||
Poor | 128 (28.2) | 26 (23.2) | 102 (31.1) | ||
AJCC 8th ed staging system | T1 | 76 (16.7) | 32 (27.8) | 44 (13.0) | 0.003 |
T2 | 202 (44.5) | 46 (40.0) | 156 (46.2) | ||
T3 | 166 (36.6) | 36 (31.3) | 130 (38.5) | ||
AJCC 8th ed staging system | N0 | 216 (47.6) | 69 (60.0) | 147 (43.4) | 0.004 |
N1 | 181 (39.9) | 31 (27.0) | 150 (44.2) | ||
N2 | 57 (12.6) | 15 (13.0) | 42 (12.4) | ||
Lymphovascular invasion | Positive | 219 (48.2) | 44 (38.3) | 175 (51.6) | 0.011 |
Negative | 219 (48.2) | 69 (60.0) | 150 (44.2) | ||
Indetermi-nant | 16 (3.5) | 2 (1.7) | 14 (4.1) | ||
Perineural invasion | Positive | 366 (80.6) | 80 (69.6) | 286 (84.4) | 0.001 |
Negative | 82 (18.1) | 34 (29.6) | 48 (14.2) | ||
Indetermi-nant | 6 (1.3) | 1 (0.9) | 5 (1.5) | ||
Recurrence/metastasis | Present | 218 (48.0) | 43 (37.4) | 175 (51.6) | 0.015 |
Absent | 236 (52.0) | 72 (62.6) | 164 (48.4) | ||
Splenic parenchymal invasion | Present | 25 (5.5) | 2 (1.7) | 23 (6.9) | 0.067 |
Absent | 425 (93.6) | 113 (98.3) | 312 (93.1) |
- Citation: Yin F, Saad M, Xie H, Lin J, Jackson CR, Ren B, Lawson C, Karamchandani DM, Bernabeu BQ, Jiang W, Dhir T, Zheng R, Schultz CW, Zhang D, Thomas CL, Zhang X, Lai J, Schild M, Zhang X, Liu X. Validation of American Joint Committee on Cancer 8th edition of TNM staging in resected distal pancreatic cancer. World J Gastrointest Pharmacol Ther 2020; 11(2): 25-39
- URL: https://www.wjgnet.com/2150-5349/full/v11/i2/25.htm
- DOI: https://dx.doi.org/10.4292/wjgpt.v11.i2.25