Effect of anesthetics on gastric damage using two models of portal hypertension

Figure 1 Gastric damage in control and portal hypertensive rats. Ethanol (EtOH)-induced gastric damage was significantly increased in cirrhotic bile duct ligation (BDL) rats compared to controls when sodium pentobarbitone (SP) anesthetic was administered. In BLD rats, ketamine/xylazine (KX) anesthesia partially restored the resistance of the portal hypertensive gastric mucosa to ethanol-induced damage. An inverse effect was obtained from KX and SP anesthetics in portal vein stenosis rats. Asterisks denote significant differences between the two anesthesia treatments in BDL and portal vein stenosis rats (n = 5; ^aP < 0.001; ^bP < 0.05). PVS: Portal vein stenosis.