Hepatic encephalopathy therapy: An overview

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Apr 6, 2010 (publication date) through Jul 18, 2024

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World Journal of Gastrointestinal Pharmacology and Therapeutics

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2150-5349

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pharmacol Ther. Apr 6, 2010; 1(2): 54-63
Published online Apr 6, 2010. doi: 10.4292/wjgpt.v1.i2.54

Table 5 Possible future approaches to HE treatment

Objectives	Approaches currently used	Proposed approaches under evaluation
To reduce the production of Gut-derived toxins	Disaccharides Low-absorbable antibiotics	Probiotics Fermentable fibers, acarbose Spherical adsorptive carbon (AST 120)
To favor nitrogen metabolism	Liver transplantation Reduction of TIPS diameter Closure of a spontaneous portal systemic shunt Ornithine Aspartate Zinc Sodium benzoate	Artificial liver support Sodium benzoate + phenylacetate (Ammonul) L-ornithine phenylacetate HPN-100 (Phenylbutyrate + phenylacetic acid)
To correct the alterations in neurotransmission	BCAA Flumazenil

Citation: Riggio O, Ridola L, Pasquale C. Hepatic encephalopathy therapy: An overview. World J Gastrointest Pharmacol Ther 2010; 1(2): 54-63
URL: https://www.wjgnet.com/2150-5349/full/v1/i2/54.htm
DOI: https://dx.doi.org/10.4292/wjgpt.v1.i2.54