Paneth cells in intestinal physiology and pathophysiology

Figure 3 Examples of Paneth cell metaplasia throughout the intestinal tract. A: Paneth cell metaplasia (arrows) in Barrett mucosa. Squamous epithelia of the oesophagus are marked with an arrowhead; B: Chronic atrophic gastritis with Paneth cell metaplasia (arrow); C: Paneth cell metaplasia (arrows) of Brunner’s gland. In the upper part, small intestinal mucosa and secretory ducts are shown (arrowheads); D: Colon mucosa in ulcerative colitis with disturbed crypt architecture, increased numbers of stroma infiltrating inflammatory cells, and Paneth cell metaplasia (arrowheads); E: Higher magnification of ulcerative colitis-associated Paneth cell metaplasia (arrows) in colon mucosa as demonstrated in (D); F: Paneth cell metaplasia (arrows) in tubular adenoma of the colon with low-grade dysplasia.