Paneth cells in intestinal physiology and pathophysiology

Figure 1 Normal small intestinal crypts with basal orientated Paneth cells. A: Paneth cells are characterised by their apical located granules (arrows). Between Paneth cells undifferentiated progenitor cells are found. In the normal Lamina propria mucosae a mixed population of immune cells and stroma resident cells is found; B: Occasionally, Paneth cells at the bottom of small intestinal crypts are mixed up with enteroendocrine cells (arrow). They are characterised by basal located granules. In the upper part of the crypt, a mitotic figure is shown.