Multiple endocrine neoplasia 2B: Differential increase in enteric nerve subgroups in muscle and mucosa

Figure 2 Thickness of muscle layers and ganglia and density of nerve fibres in normal colon and MEN2B colon. A: Comparison of thickness (mm) of muscle and myenteric ganglia in colon from Control (HSCR and FAP) and MEN2B patient. Graph shows mean and SEM. HSCR n = 6, FAP n = 12, MEN2B n = 24, ^aP < 0.05, ^cP < 0.001; B: Nerve fibre and ICC density in circular muscle in transverse colon from Control (HSCR and FAP combined, n = 3) and MEN2B patient (n = 3). Percent area of circular muscle containing immunoreactive pixels; C: Relative nerve fibre and ICC density in the circular muscle in MEN2B patient (n = 3) relative to Control patients (HSCR and FAP combined, n = 3). Labelling with Tuj1, NOS, VIP, SP and cKit (for interstitial cells of Cajal).