Rectification of oxygen transfer through the rat colonic epithelium

Table 1 Short-circuit current and oxygen consumption of the isolated mucosa of rat sigmoid colon

Treatment	n	Isc μmol × cm-2 × h-1	Total QO2 μmol × cm-2 × h-1	Serosal QO2 μmol × cm-2 × h-1	Mucosal QO2 μmol × cm-2 × h-1
None	20	3.33 ± 0.21	2.79 ± 0.06	1.52 ± 0.04	1.28 ± 0.08b
Low Cl	6	0.66 ± 0.07	2.56 ± 0.13	1.41 ± 0.08	1.14 ± 0.06d
Bum + DPC	6	0.63 ± 0.08	2.47 ± 0.15	1.35 ± 0.07	1.15 ± 0.08d
Serotonin	6	5.30 ± 0.29	3.64 ± 0.13	1.97 ± 0.08	1.67 ± 0.06d
IBMX	6	3.98 ± 0.24	3.22 ± 0.09	1.75 ± 0.07	1.47 ± 0.06d
SDR	6	8.50 ± 0.45	3.71 ± 0.35	2.02 ± 0.15	1.68 ± 0.12b
SDR + Ami	6	0.33 ± 0.05	2.88 ± 0.12	1.53 ± 0.07	1.35 ± 0.08d

^bP < 0.0001 and

^dP < 0.01 for the difference between serosal and mucosal oxygen consumption. I_sc: Short-circuit current; QO₂: Oxygen consumption; Bum: Bumetanide; DPC: Diphenylamine-2-carboxylate; IBMX: 3-methyl-1-isobutilxanthine; SDR: Sodium-deprived rats; Ami: Amiloride.