Novel biomarkers of fibrosis in Crohn’s disease

Figure 2 The involvement of Wnt pathway in the progression from fibrosis to cancer. Patients affected by intestinal bowel disease are highly susceptible to a specific type of colorectal carcinogenesis characterized by the inflammation-dysplasia-carcinoma progression, without the appearance of adenoma. The activation of Wnt pathway in colitis could represent a possible link between fibrosis and the development of colorectal cancer.