Does the antibody production ability affect the serum anti-Helicobacter pylori IgG titer?

Table 2 Characteristics of the subjects according to the degree of H. pylori infiltration on gastric biopsy n (%)

Variables	Mild H. pylori infiltration (n = 14)	Moderate H. pylori infiltration (n = 23)	Marked H. pylori infiltration (n = 74)	P value
Age (yr, mean ± SD)	54.7 ± 8.4	57.7 ± 12.0	54.7 ± 9.0	0.428
Gender (male)	6 (42.9)	16 (69.6)	44 (59.5)	0.276
Serum anti-H. pylori IgG titer (AU/mL)1	2.39 (0.36-4.00)	3.37 (1.86-4.00)	3.95 (0.82-4.00)	< 0.001
Serum PG I level (ng/mL, mean ± SD)	58.0 ± 19.3	75.5 ± 32.6	73.6 ± 28.7	0.146
Serum PG II level (ng/mL, mean ± SD)	15.6 ± 6.3	22.9 ± 9.5	22.9 ± 9.2	0.021
Serum PG I/II ratio (mean ± SD)	4.1 ± 1.7	3.4 ± 1.0	3.4 ± 1.1	0.118
Presence of corpus gastric atrophy as reflected by PG assay	3 (21.4)	5 (21.7)	15 (20.3)	0.986
Biopsied site (antrum:body or angle:fundus or cardia)	1:3:0	15:7:1	43:26:5	0.625
Scores based on Updated Sydney system
Activity (mean ± SD)	1.5 ± 0.7	1.9 ± 0.5	2.0 ± 0.7	0.034
Inflammation (mean ± SD)	1.9 ± 0.5	2.0 ± 0.2	2.1 ± 0.4	0.052
Atrophy (median with ranges)	0.8 (0-3)	1.3 (0-3)	0.9 (0-3)	0.589
Intestinal metaplasia (median with ranges)	0.6 (0-3)	0.9 (0-3)	0.6 (0-3)	0.771
Positive HBsAb finding	9 (64.3)	17 (73.9)	52 (70.3)	0.824
HBsAb titer (mIU/mL)1	174.9 (1-1000)	120.7 (1-1000)	86.8 (1-1000)	0.601
Platelet (× 103/μL, mean ± SD)	252.2 ± 41.9	231.9 ± 51.9	233.2 ± 48.1	0.375
White blood cell count (× 103/μL, mean ± SD)	5688.6 ± 1552.3	5780.0 ± 1390.9	5908.0 ± 1678.0	0.869
Neutrophil (%)	55.1 ± 9.3	54.9 ± 10.3	45.5 ± 9.1	0.702
Lymphocyte (%)	36.8 ± 8.7	37.0 ± 9.8	36.2 ± 8.4	0.919
Monocyte (%)	4.9 ± 1.6	4.9 ± 2.1	4.6 ± 1.5	0.732
Eosinophil (%)	2.4 (0-6)	2.0 (0-1)	1.8 (0-1)	0.819
Basophil (%)	0.4 (0-1)	0.5 (0-1)	0.4 (0-5)	0.771

¹Values are shown as median with ranges due to asymmetrical distribution. HBsAb: Hepatitis B surface antibody; PG: Pepsinogen; H. pylori: Helicobacter pylori.