Neurophysiological mechanisms of bradykinin-evoked mucosal chloride secretion in guinea pig small intestine

Figure 8 Overview of metabotropic signal transduction cascade for bradykinin evoked chloride secretion in the submucosal plexus of the guinea pig small intestine. Bradykinin activates B2R receptor, G protein, phospholipase C, PIP2 hydrolysis, IP3 and DAG generation, Ca²⁺-Camodulin, PKC and CaMkinases, cation channel open, and chloride secretion. Termination of chloride secretion is postulated to result from activation of the intraneutonal phosphatase, calcineurin. The blocking agents for each of the steps are included in the figure. PLC: Phospholipase C; PKC: Protein kinase C; PGE₂: Prostaglandin E2.