Neurophysiological mechanisms of bradykinin-evoked mucosal chloride secretion in guinea pig small intestine

Figure 5 Bradykinin-evoked increase in short-circuit current is mainly mediated by the prostaglandin E2 receptors. A: Pretreatment with EP receptors antagonist AH6809, SC-19220 (a selective antagonist of EP1 receptor), or GW627368X (a selective antagonist of EP4 receptor) suppressed BK-evoked Isc (P < 0.01); B: Quantitative data showing the effect of AH6809, Sc-19220 and GW627368X on BK-evoked response in Isc. The vertical axis represents the changes of Isc. Values are expressed as mean ± SE, n = 6-12 animals. ^eP < 0.01 (compared to BK alone). BK: Bradykinin; PGE₂: Prostaglandin E2; Isc: Increase in short-circuit current.