Neurophysiological mechanisms of bradykinin-evoked mucosal chloride secretion in guinea pig small intestine

Figure 4 Bradykinin-induced prostaglandin E2 production in submucosal preparations is mediated by both COX-1 and COX-2. Preincubation of submucosal preparations with BK (10 nM) for 10 min or 3 h significantly increased PGE2 production and this was suppressed by the COX-1 inhibitor FR122047 (1 μM ) or the COX-2 inhibitor NS398 (10 μM). Values are expressed as mean ± SE, n = 3 independent samples, each assayed in duplicate. ^cP < 0.01 BK vs control; ^eP < 0.01 pretreated with agents vs BK alone. BK: Bradykinin; PGE2: Prostaglandin E2.