Neurophysiological mechanisms of bradykinin-evoked mucosal chloride secretion in guinea pig small intestine

Figure 3 Cyclooxygenase inhibitors suppress bradykinin-evoked increase in short-circuit current. A: Pretreatment with the COX-2 inhibitor NS398, COX1 inhibitor FR122047 (1 μM), non-specific COX inhibitors indomethacin or piroxicam suppressed BK-evoked Isc; B: Quantitative data showing the effect of COX inhibitors on BK-evoked increase in Isc. Values are expressed as mean ± SE, n = 6 animals. ^eP < 0.01 vs BK alone. COX: Cyclooxygenase; BK: Bradykinin; Isc: Increase in short-circuit current.